2024/04/10現在

学術論文

Domon, H., Hirayama, S., Isono, T., Saito, R., Yanagihara, K., and Terao, Y.: Lipoprotein signal peptidase-deficient Streptococcus pneumoniae exhibits impaired Toll-like receptor 2-stimulatory activity. Microbiol. Immunol., 68(4):155-159, 2024.

Sirisereephap, K., Tamura, H., Lim, JH., Surboyo, MDC., Isono, T., Hiyoshi, T., Rosenkranz, AL., Sato-Yamada, Y., Domon, H., Ikeda, A., Hirose, T., Sunazuka, T., Yoshiba, N., Okada, H., Terao, Y., Maeda, T., Tabeta, K., Chavakis, T., Hajishengallis, G., and Maekawa, T.: A novel macrolide-Del-1 axis to regenerate bone in old age. iScience, 27(2): 108798, 2024.

Isono, T., Hirayama, S., Domon, H., and Terao, Y.: Pneumococcus downregulates the molecular weight of the extracellular domain of the epidermal growth factor receptor of alveolar epithelial cells. Microbiol. Immunol., 68(1) 23-26, 2024.

Yasui, Y., Hirayama, S., Hiyoshi, T., Isono, T., Domon, H., Maekawa, T., Tabeta, K., and Terao, Y.: The pneumococcal protein SufC binds to host plasminogen and promotes its conversion to plasmin. Microorganisms, 11(12): 2969, 2023.

Nirei, J., Kobayashi, A., Habuka, R., Domon, H., Terao, Y., and Saitoh A.: Cord blood granulocyte colony-stimulating factor level as an optimal predictor of umbilical cord arteritis associated with brain injury at term equivalent age in preterm neonates. Cytokine, 171(11): 156369, 2023.

Domon, H., Hirayama, S., Isono, T., Sasagawa, K., Takizawa, F., Maekawa, T., Yanagihara, K., and Terao, Y.: Macrolides decrease the proinflammatory activity of macrolide-resistant Streptococcus pneumoniae. Microbiol. Spectr., 11(3): e00148-23, 2023.

Takenaka, S., Moro, H., Shimizu, U., Koizumi, T., Nagano, K., Edanami, N., Ohkura, N., Domon, H., Terao, Y., and Noiri, Y.: Preparing of point-of-care reagents for risk assessment in the elderly at home by a home-visit nurse and verification of their snalytical accuracy. Diagnostics, 13(14): 2407, 2023.

Nakao, R., Hirayama, S., Yamaguchi, T., Senpuku, H., Hasegawa, H., Suzuki, T., Akeda, Y., and Ohnishi, M.: A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria. Vaccine., 41(30): 4369-4383, 2023.

Isono, T., Hirayama, S., Domon, H., Maekawa, T., Tamura, H., Hiyoshi, T., Sirisereephap, K., Takenaka, S., Noiri, Y., and Terao, Y.: Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia., J. Biol. Chem., 99(6): 104760, 2023.

Hirayama, S., Hiyoshi, T., Yasui, Y., Domon, H., and Terao, Y.: C-terminal lysine residue of pneumococcal triosephosphate isomerase contributes to its binding to host plasminogen. Microorganisms, 11(5): 1198, 2023.

Takizawa, F., Domon, H., Hiyoshi, T., Tamura, H., Shimizu, K., Maekawa, T., Tabeta, K., Ushida, A., and Terao, Y.: Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLOS ONE, 18(4): e0284115, 2023.

Tamura, H., Maekawa, T., Domon, H., Sirisereephap, K., Isono, T., Hirayama, S., Hiyoshi, T., Sasagawa, K., Takizawa, F., Maeda, T., Terao, Y., and Tabeta, K.: Erythromycin restores osteoblast differentiation and osteogenesis suppressed by Porphyromonas gingivalis lipopolysaccharide. Pharmaceuticals, 16(2): 303, 2023.

Hirayama, S., Yasui, Y., Sasagawa, K., Domon, H., and Terao, Y.: Pneumococcal proteins ClpC and UvrC as novel host plasminogen binding factors. Microbiol. Immunol., 67(2): 99-104, 2023.

Nakao, R., Kobayashi, H., Iwabuchi, Y., Kawahara, K., Hirayama, S., Ramstedt, M., Sasaki, Y., Kataoka, M., Akeda, Y., Ohnishi, M.: A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles. NPJ Vaccines, 7: 153, 2022.

Ibano, N., Inada, E., Otake, S., Kiyokawa, Y., Sakata, K., Sato, M., Kubota, N., Noguchi, H., Iwase, Y., Murakami, T., Sawami, T., Kakihara, Y., Maeda, T., Terunuma, M., Terao, Y., and Saitoh, S.: The role of genetically modified human feeder cells in maintaining the integrity of primary cultured human deciduous dental pulp cells. J. Clin. Med., 11(20): 6087, 2022.

Mizuno, K., Maree, M., Nagamura, T., Koga, A., Hirayama, S., Furukawa, S., Tanaka, K., Morikawa, K.: Novel multicellular prokaryote discovered next to an underground stream. eLife, 11: e71920, 2022.

Hirayama, S., Domon, H., Hiyoshi, T., Isono, T., Tamura, H., Sasagawa, K., Takizawa, F., and Terao, Y.: Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. FEBS Open Bio, 12(6): 1206-1219, 2022.

Hiyoshi, T., Domon, H., Maekawa, T., Tamura, H., Isono, T., Hirayama, S., Sasagawa, K., Takizawa, F., Tabeta, K., and Terao, Y.: Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules. Scientific Reports, 12: 8159, 2022.

Sirisereephap, K., Maekawa, T., Tamura, H., Hiyoshi, T., Domon, H., Isono, T., Terao, Y., Maeda, T., and Tabeta, K.: Osteoimmunology in periodontitis: Local proteins and compounds to alleviate periodontitis. Int. J. Mol. Sci., 23(10): 5540, 2022.

Sasaki, Y., Hirayama, S., and Nakao, R.: Scanning electron microscopy of Escherichia coli encapsulated in a spacerized graphene sandwich. Microscopy, 71(3):175-180, 2022.

Sasagawa, K., Domon, H., Sakagami, R., Hirayama, S., Maekawa, T., Isono, T., Hiyoshi, T., Tamura, H., Takizawa, F., Fukushima, Y., Tabeta, K., and Terao, Y.: Matcha green tea exhibits bactericidal activity against Streptococcus pneumoniae and inhibits functional pneumolysin. Antibiotics, 10(12): 1550, 2021.

Domon, H., Isono, T., Hiyoshi, T., Tamura, H., Sasagawa, K., Maekawa, T., Hirayama, S., Yanagihara, K., and Terao, Y.: Clarithromycin inhibits pneumolysin production via downregulation of ply gene transcription despite autolysis activation. Microbiol. Spectr., 9(2): e00318-21, 2021.

Hirayama, S., and Nakao, R.: Glycine induction method – Effective production of immunoactive bacterial membrane vesicles with low endotoxin content. Methods Mol. Biol. (published by Springer Nature), 2022;2414: 207-226, 2021.

Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Hirayama, S., Isono, T., Sasagawa, K., Yonezawa, D., Takahashi, N., Oda, M., Maeda, T., Tabeta, K., and Terao, Y.: Effects of erythromycin on osteoclasts and bone resorption via DEL-1 induction in mice. Antibiotics, 10(3): 312, 2021.

Domon, H., and Terao, Y.: The role of neutrophils and neutrophil elastase in pneumococcal pneumonia. Front. Cell. Infect. Microbiol., March Vol. 11, Article 615959, eCollection, 2021.

Domon, H., Maekawa, T., Isono, T., Furuta, K., Kaito, C., and Terao, Y.: Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia. Scientific Reports, 11: 2432, 2021.

Matsugishi, A., Aoki-Nonaka, Y., Yokoji-Takeuchi, M., Yamada-Hara, M., Mikami, M., Hayatsu, M., Terao, Y., Domon, H., Taniguchi, M., Takahashi, N., Yamazaki, K., and Tabeta, K.: Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum. Arch. Oral Biol., 121(1): 104956, 2021.

Macleod, T., Ainscough, JS., Hesse, C., Konzok, S., Braun, A., Buhl, A., Wenzel, J., Bowyer, P., Terao, Y., Herrick, S., Wittmann, M., and Stacey, M.: The proinflammatory cytokine IL-36γ is a global discriminator of harmless microbes and invasive pathogens within epithelial tissues. Cell Rep., 33(11): 108515, 2020.

Isono, T., Domon, H., Nagai, K., Maekawa, T., Tamura, H., Hiyoshi, T., Yanagihara, K., Kunitomo, E., Takenaka, S., Noiri, Y., and Terao, Y.: Treatment of severe pneumonia by hinokitiol in a murine antibiotic-resistant pneumococcal pneumonia model. PLOS ONE, 15(10): e0240329, 2020.

Tamura, H., Maekawa, T., Hiyoshi, T., and Terao, Y.: Animal model of periodontitis ― Analysis of experimental ligature-induced periodontitis model in mice ―. Methods Mol. Biol.: Periodontal Pathogens (published by Springer Nature), 2021;2210: 237-250, 2020.

Hasegawa, T., Takenaka, S., Oda, M., Domon, H., Hiyoshi, T., Sasagawa, K., Ohsumi, T., Hayashi, N., Okamoto, Y., Yamamoto, H., Ohshima, H., Terao, Y., and Noiri, Y.: Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability. BMC Microbiol., 20: 361, 2020.

Hirayama, S., and Nakao, R.: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: Isolation method and application to a mouse model. Methods Mol. Biol.: Periodontal Pathogens (published by Springer Nature), 2021;2210: 157-166, 2020.

Maekawa, T., Tamura, H., Domon, H., Hiyoshi, T., Isono, T., Yonezawa, D., Hayashi, N., Takahashi, N., Tabeta, K., Maeda, T., Oda, M., Ziogas, A., Alexaki, VI., Chavakis, T., Terao, Y., and Hajishengallis, G.: Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1. JCI Insight, 5(15): e136706, 2020.

Habuka, R., Aizawa, Y., Izumita, R., Domon, H., Terao, Y., Takihara, H., Okuda, S., and Saitoh, A.: Innate immune responses in serum and cerebrospinal fluid from neonates and infants infected with parechovirus-A3 or enteroviruses. J. Infect. Dis., 222(4): 681-689, 2020.

Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Takenaka, S., Osumi, T., Maekawa, T., Yamasaki, N., and Terao, Y.: Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. Microbiol. Immunol., 64(7): 493-501, 2020.

Hirayama, S., and Nakao, R.: Glycine significantly enhances bacterial membrane vesicle production: a powerful approach for isolation of LPS-reduced membrane vesicles of probiotic Escherichia coli. Microb. Biotechnol., 13(4): 1162-1178, 2020.

Nakamura, T., Iwabuchi, Y., Hirayama, S., Narisawa, N., Takenaga, F., Nakao, R., and Senpuku, H.: Roles of membrane vesicles from Streptococcus mutans for the induction of antibodies to glucosyltransferase in mucosal immunity., Microb. Pathog., 149(12): 104260, 2020.

Ohsumi, T., Takenaka, S., Sakaue, Y., Suzuki, Y., Nagata, R., Hasegawa, T., Ohshima, H., Terao, Y., and Noiri, Y.: Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study. BMC Oral Health, 20: 161, 2020.

Hiyoshi, T., Domon, H., Maekawa, T., Yonezawa, D., Kunitomo, E., Tabeta, K., and Terao, Y.: Protective effect of hinokitiol against periodontal bone loss in ligature induced experimental periodontitis in mice. Arch. Oral Biol., 112(4): 104679, 2020.

Suzuki, Y., Ohsumi, T., Isono, T., Nagata, R., Hasegawa, T., Takenaka, S., Terao, Y., and Noiri, Y.: Effects of sub-minimum inhibitory concentration of chlorhexidine gluconate on development of in vitro multi-species biofilms. Biofouling, 36(2): 146-158, 2020.

Ziogas, A., Maekawa, T., Wiessner, RJ., Le, TT., Sprott, D., Troullinaki, M., Neuwirth, A., Anastasopoulou, V., Grossklaus, S., Chung, K., Sperandio, M., Chavakis, T., Hajishengallis, G., and Alexaki, VI.: DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist Del-1. J. Immunol., 204(5): 1214-1224, 2020.

Hasegawa, T., Takenaka, S., Ohsumi, T., Ida, T., Ohshima, H., Terao, Y., Traithawit, N., Maeda, T., and Noiri, Y.: Effect of a novel glass ionomer cement containing flour-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin. Oral Investig., 24(2): 963–970, 2020.

Domon, H., Hiyoshi, T., Maekawa, T., Yonezawa, D., Tamura, H., Kawabata, S., Yanagihara, K., Kimura, O., Kunitomo, E., and Terao, Y.: Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways. Microbiol. Immunol., 63: 213-222, 2019.

Hiyoshi, T., Domon, H., Maekawa, T., Nagai, K., Tamura, H., Takahashi, N., Yonezawa, D., Miyoshi, T., Yoshida, A., Tabeta, K., and Terao, Y.: Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. Microbiol. Immunol., 63: 100-110, 2019.

Nagai, K., Kimura, O., Domon, H., Maekawa, T., Yonezawa, D., and Terao, Y.: Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J. Infect. Chemother., 25(3): 229-232, 2019.

Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Yonezawa, D., Nagai, K., Ochiai, A., Taniguchi, M., Tabeta, K., Maeda, T., and Terao, Y.: Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. Arch. Oral Biol., 98: 132-139, 2019.

Nagai, K., Domon, H., Maekawa, T., Hiyoshi, T., Tamura, H., Yonezawa, D., Habuka, R., Saitoh, A., and Terao, Y.: Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection. Vaccine, 37: 160-168, 2019.

Yamaguchi, M., Hirose, Y., Takemura, M., Ono, M., Sumitomo, T., Nakata, M., Terao, Y., and Kawabata, S.: Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. Front. Cell. Infect. Microbiol., August Vol. 9, Article 301, eCollection, 2019.

Soda, M., Saitoh, I., Murakami, T., Inada, E., Iwase, Y., Noguchi, H., Shibasaki, S., Kurosawa, M., Sawami, T., Terunuma, M., Kubota, N., Terao, Y., Ohshima, H., Hayasaki, H., and Sato, M.: Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability. Scientific Reports, 9: 1490, 2019.

Aoki-Nonaka, Y., Tabeta, K., Yokoji, M., Matsugishi, A., Matsuda, Y., Takahashi, N., Sulijaya, B., Domon, H., Terao, Y., Taniguchi, M., and Yamazaki, K.: The AmyI‐1‐18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin‐1β in mice. J. Periodontol., 90(10):1160-1169, 2019.

Hasegawa, T., Takenaka, S., Wakamatsu, R., Ohsumi, T., Domon, H., Ohshima, H., Terao, Y., and Noiri, Y.: A horizontal sequential cutting method to estimate the effectiveness of dentin disinfection by using confocal laser scanning microscopy. J Endod., 45: 1142–1147, 2019.

Senpuku, H, Nakamura, T., Iwabuchi, Y., Hirayama, S., Nakao, R., and Ohnishi, M.: Effects of Complex DNA and MVs with GTF Extracted from Streptococcus mutans on the Oral Biofilm. Molecules, 24(17): 313, 2019.

Domon, H., Maekawa, T., Yonezawa, D., Nagai, K., Oda, M., Yanagihara, K., and Terao, Y.: Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother., 62(11): e00161-18, 2018.

Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Microbiol. Immunol., 62: 617-623, 2018.

Domon, H., Nagai, K., Maekawa, T., Oda, M., Yonezawa, D., Takeda, W., Hiyoshi, T., Tamura, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia. Front. Immunol., April Vol. 9, Article 732, eCollection, 2018.

Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Kimura, T., Isono, T., Maekawa, T., Hayashi, N., Yamada, N., Furue, Y., Kai, D., and Terao, Y.: Sulfated vizantin induces the formation of macrophage extracellular traps. Microbiol. Immunol., 62: 310-316, 2018.

Sakaue, Y., Takenaka, S., Ohsumi, T., Domon, H., Terao, Y., and Noiri, Y.: The effect of chlorhexidine on dental calculus formation: an in vitro study. BMC Oral Health, 18: 52, 2018.

Sumitomo, T., Mori, Y., Nakamura, Y., Honda-Ogawa, M., Nakagawa, S., Yamaguchi, M., Matsue, H., Terao, Y., Nakata, M., and Kawabata, S.: Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. Front. Cell. Infect. Microbiol., January Vol. 8, Article 10, eCollection, 2018.

Nagai, K., Domon, H., Maekawa, T., Oda, M., Hiyoshi, T., Tamura, H., Yonezawa, D., Arai, Y., Yokoji, M., Tabeta, K., Habuka, R., Saitoh, A., Yamaguchi, M., Kawabata, S., and Terao, Y. : Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol., 325: 14-22, 2018.

Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Microb. Infect., 20: 9-18, 2018.

Mitroulis, I., Chen, L. S., Singh, R. P., Kourtzelis, I., Economopoulou, M., Kajikawa, T., Troullinaki, M., Ziogas, A., Ruppova, K., Hosur, K., Maekawa, T., Wang, B., Subramanian, P., Tonn, T., Verginis, P., von Bonin, M., Wobus, M., Bornhäuser, M., Grinenko, T., Di Scala, M., Hidalgo, A., Wielockx, B., Hajishengallis, G., and Chavakis, T.: Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J. Clin. Invest., 127: 3624-3639, 2017.

Oda, M., Domon, H., Kurosawa, M., Isono, T., Maekawa, T., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. Front. Cell. Infect. Microbiol., June Vol. 7, Article 300, eCollection, 2017.

Kajikawa, T., Meshikhes, F., Maekawa, T., Hajishengallis, E., Hosur, K. B., Abe, T., Moss, K., Chavakis, T., and Hajishengallis, G.: Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans. J. Clin. Periodontol., 44: 472-483, 2017.

Maekawa, T., Kulwattanaporn, P., Hosur, K., Domon, H., Oda, M., Terao, Y., Maeda, T., and Hajishengallis, G.: Differential expression and roles of secreted frizzled-related protein 5 (Sfrp5) and the wingless homolog Wnt5a in periodontitis. J. Dent. Res., 96: 571-577, 2017.

Murakami, T., Saitoh, I., Sato, M., Inada, E., Soda, M., Oda, M., Domon, H., Iwase, Y., Sawami, T., Matsueda, K., Terao, Y., Ohshima, H., Noguchi, H., and Hayasaki, H.: Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. Arch. Oral Biol. 81: 110-120, 2017.

Nagai, K., Domon, H., Oda, M., Shirai, T., Ohsumi, T., Terao, Y., and Arai, Y.: Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria. Dental Materials Journal, 480:173-179, 2016.

Domon, H., Oda, M., Maekawa, T., Nagai, K., Takeda, W., and Terao, Y.: Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. Scientific Reports, 6: 38013, 2016.

Takenaka, S., Oda, M., Domon, H., Ohsumi, T., Suzuki, Y., Ohshima, H., Yamamoto, H., Terao, Y., and Noiri, Y.: Vizantin inhibits bacterial adhesion without affecting bacterial growth and causes Streptococcus mutans biofilm to detach by altering its internal architecture. Biochem. Biophys. Res. Commun., 480: 173-179, 2016.

Yamamoto, H., Oda, M., Kanno, M., Tamashiro, S., Tamura, I., Yoneda, T., Yamasaki, N., Domon, H., Nakano M., Takahashi, H., Terao, Y., Kasai, Y., and Imagawa, H.: Chemical hybridization of Vizantin and Lipid A to generate a novel LPS antagonist. Chem. Pham. Bull., 64: 246-257, 2016.

Sakaue, Y., Domon, H., Oda, M., Takenaka, S., Kubo, M., Fukuyama, Y., Okiji, T., and Terao, Y.: Anti-biofilm and bactericidal effects of Magnolia bark-derived magnolol and honokiol on Streptococcus mutans. Microbiol. Immunol., 60:10-16, 2016.

Kurosawa, M., Oda, M., Domon, H., Saitoh, I., Hayasaki, H., and Terao, Y.: Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells. Microb. Infect., 18: 118-127, 2016.

Domon, H., Uehara, Y., Oda, M., Seo, H., Kubota, N., and Terao, Y.: Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces. MicrobiologyOpen, 5: 39-346, 2016.

Maekawa, T., Briones, R. A., Resuello, R. R., Kajikawa, T., Lambris, J. D., and Hajishengallis, G.: Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol., 43: 238-49, 2016.

Kubo, M., Nishikawa, Y., Harada, K., Oda, M., Huang, JM., Domon, H., Terao, Y., and Fukuyama, Y.: Tetranorsesquiterpenoids and santalane-type sesquiterpenoids from Illicium lanceolatum and their antimicrobial activity against the oral pathogen Porphyromonas gingivalis. J. Nat. Prod., 78: 1466-1469, 2015.

Takagishi, T., Oda, M., Kabura, M., Kurosawa, M., Tominaga, K., Urano, S., Ueda, Y.,Kobayashi, K., Kobayashi, T., Sakurai, J., Terao, Y., and Nagahama, M.: Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane. PLoS one, 10; e0120497, 2015.

Maekawa, T., Hosur, K., Abe, T., Kantarci, A., Van Dyke, TE., Chavakis, T., and Hajishengallis, G.: Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. Nature Commun., 6:8272, doi: 10.1038/ncomms9272, 2015.

Shin, J., Maekawa, T., Abe, T., Hajishengallis, E., Hosur, K., Chavakis, T., and Hajishengallis, G.: The homeostatic factor Del-1 restrains osteoclastogenesis and inhibits bone loss in non-human primates. Science Transl. Med., 7(307): 307ra155, doi: 10.1126/scitranslmed.aac5380, 2015.

Hajishengallis, G., Maekawa, T., Abe, T., Hajishengallis, E., and Lambris, J. D.: Complement Involvement in Periodontitis: Molecular mechanisms and rational therapeutic approaches. Adv. Exp. Med. Biol., 865: 57-74, 2015.

Abe, T., AlSarhan, M., Benakanakere, M. R., Maekawa, T., Kinane, D. F., Cancro, M. P., Korostoff, J. M., and Hajishengallis, G.: The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis. J. Immunol., 195:1427-35, 2015.

Ohsumi, T., Takenaka, S., Wakamatsu, R., Sakaue, Y., Narisawa, N., Senpuku, H., Ohshima, H., Terao, Y., and Okiji, T.: Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development. PLoS one, 10: e0116647, 2015.

Oda, M., Yamamoto, H., Shibutani, M., Nakano, M., Yabiku, K., Tarui, T., Kameyama, N., Shirakawa, D., Obayashi, S., Watanabe, N., Nakase, H., Suenaga, M., Matsunaga, Y., Nagahama, M., Takahashi, H., Imagawa, H., Kurosawa, M., Terao, Y., Nishizawa, M., and Sakurai, J.: Vizantin inhibits endotoxin-mediated immune responses via the Toll-like receptor 4/MD-2 complex. J. Immunol., 193: 4507-4514, 2014.

Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K.: Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis. J. Periodontal Res., 49: 536-543, 2014.

Aoki-Nonaka, Y., Nakajima, T., Miyauchi, S., Miyazawa, H., Yamada, H., Domon, H., Tabeta, K., and Yamazaki, K.: Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis. J. Periodontal Res., 49: 69-76, 2014.

Maekawa, T., Krauss, J. L., Abe, T., Jotwani, R., Triantafilou, M., Triantafilou, K., Hashim, A., Hoch, S., Curtis, M. A., Nussbaum, G., Lambris, J. D., and Hajishengallis, G.: Proactive microbial manipulation of complement and Toll-like receptor signaling to promote dysbiosis by uncoupling bacterial clearance from inflammation. Cell Host Microbe., 15: 768-78, 2014.

Maekawa, T., Abe, T., Hajishengallis, E., Hosur, KB., DeAngelis, R., Ricklin, D., Lambris, J. D., and Hajishengallis, G.: Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. J. Immunol., 192: 6020-6027, 2014.

Maekawa, T., and Hajishengallis, G.: Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J. Periodontal. Res., 49: 785-91, 2014.

Maekawa, T.: Investigation of Wnt5a and sFRP5 expressions in healthy and chronic periodontitis tissues. Niigata. Dent. J., 45: 21-28, 2014.

Wakamatsu, R., Takenaka, S., Ohsumi, T., Terao, Y., Ohshima, H., and Okiji, T.: Penetration kinetics of four mouthrinses into Streptococcus mutans biofilms analyzed by direct time-lapse visualization. Clin. Oral Invest., 8: 625-634, 2014.

Nohara, F., Nagaya, K., Asai, H., Tsuchida, E., Okamoto, T., Hayashi, T., Sakata, H., Terao, Y., and Azuma, H.: Neonatal pleural empyema caused by emm type 6 group A Streptococcus. Pediatirics International, 55: 519-521, 2013.

Murakami, T., Saitoh, I., Inada, E., Kurosawa, M., Iwase, Y., Noguchi, H., Terao, Y., Yamasaki, Y., Hayasaki, H., and Sato, M.: STO feeder cells are useful for propagation of primarily cultured human deciduous dental pulp cells in view of elimination of contaminated bacteria and promotion of cellular outgrowth. Cell Medicine, 6: 75-81, 2013.

Yamaguchi, M., Terao, Y.*, Mori-Yamaguchi, M., Domon, H., Sakaue, Y., Yagi, T., Nishino, K., Yamaguchi, A., Nizet, V., and Kawabata, S.: Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS one, 8: e77282, 2013.

Honda-Ogawa, M., Ogawa, T., Terao, Y.*, Sumitomo, T., Nakata, M., Ikebe, K., Maeda, Y., and Kawabata, S.: Cysteine proteinase from Streptococcus pyogenes enables to evade innate immunity via degradation of complement factors. J. Biol. Chem., 288: 15854-15864, 2013.

Yamaguchi, M., Terao, Y., and Kawabata, S.: Pleiotropic virulence factor – Streptococcus pyogenes fibronectin-binding proteins. Cell. Microbiol., 15: 503-511, 2013.

Sumitomo, T., Nakata, M., Higashino, M., Terao, Y., and Kawabata, S.: Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation. J. Biol. Chem., 288: 13317-13324, 2013.

Okahashi, N., Nakata, M., Sumitomo, T., Terao, Y., and Kawabata, S.: Hydrogen peroxide produced by oral streptococci induces macrophage cell death. PLoS one, 8: e62563, 2013.

Ogawa, T., Terao, Y., Honda-Ogawa, M., Hashimoto, S., Ikebe, K., Maeda, Y., and Kawabata, S.: MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro study. Microb. Infect., 15:212-218, 2013.

Hajishengallis, G., Maekawa, T., Abe, T., Hajishengallis, E., and Lambris, J. D.: Complement involvement in periodontitis: Mechanisms and therapeutic intervention. Molecular Immunology., 56: 265-7, 2013.

Hajishengallis, G., Abe, T., Maekawa, T., Hajishengallis, E., and Lambris, J. D.: Role of complement in host-microbe homeostasis of the periodontium. Semin. Immunol., 25: 65-72. 2013.

Murakami, J., Terao, Y., Morisaki, I., Hamada, S., and Kawabata, S.: Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone protein. J. Biol. Chem., 287: 22266-22275, 2012.

Mori, Y., Yamaguchi, M., Terao, Y.*, Hamada, S., Ooshima, T., and Kawabata, S.: α-enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps. J. Biol. Chem., 287: 10472-10481, 2012.

Ogawa, T., Yamasaki, S., Honda, M., Terao, Y., Kawabata, S., and Maeda, Y.: Long-term survival of salivary streptococci on dental devices made of EVA. Int. J. Oral Science, 4:14-18, 2012.

Kimura, K. R., Nakata, M., Sumitomo, T., Kreikemeyer, B., Podbielski, A., Terao, Y., and Kawabata, S.: Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes. J. Bacteriol., 194: 804-812, 2012.

Sumitomo, T., Nakata, M., Yamaguchi, M., Terao, Y., and Kawabata S.: S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. J. Med. Microbiol., 61: 101-108, 2012.

Miyazawa, H., Tabeta, K., Miyauchi, S., Aoki-Nonaka, Y., Domon, H., Honda, T., Nakajima, T., and Yamazaki, K.: Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice. Lipids Health Dis., 11:121, 2012.

Miyazawa, H., Honda, T., Miyauchi, S., Domon, H., Okui, T., Nakajima, T., Tabeta, K., and Yamazaki, K.: Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. Clin. Chim. Acta, 413(1-2): 154-159, 2012.

Miyauch, S., Maekawa, T., Aoki, Y., Miyazawa, H., Tabeta, K., Nakajima, T., and Yamazaki, K.: Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE shl mice. J. Periodontal. Res., 47: 402-8, 2012.

Miyashita, H., Honda, T., Maekawa, T., Takahashi, N., Aoki, Y., Nakajima, T., Tabeta, K., and Yamazaki, K.: Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis. Arch. Oral. Biol., 57: 820-829, 2012.

Nakata, M., Kimura, K. R., Sumitomo, T., Wada, S., Sugauchi, A., Oki, E., Higashino, M., Kreikemeyer, B., Podbielski, A., Okahashi, N., Hamada, S., Isoda, R., Terao, Y., and Kawabata, S.: Assembly mechanism of FCT type 1 pili in serotype M6 Streptococcus pyogenes. J. Biol. Chem., 286: 37566-37577, 2011.

Okahashi, N., Okinaga T., Sakurai, A., Terao, Y., Nakata M. Nakashima K., Shintani S., Kawabata S., Ooshima T., and Nishihara T.: Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species. FEMS Microbiol. Lett., 323:164-170, 2011.

Hoshino, T., Kondo, Y., Saito, K., Terao, Y., Okahashi, N., Kawabata, S., and Fujiwara, T.: Novel epitopic region of glucosyltransferase B from Streptococcus mutans. Clin. Vaccine Immunol., 18:1552-1561, 2011.

Baatarjav, T., Kataoka, K., Gilbert, R. S., Terao, Y., Fukui, M., Goto, M., Kawabata, S., Yamamoto, M., Fujihashi, K., and Ito, H. O.: Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination. Vaccine, 79:2819-2828, 2011.

Ogawa, T., Terao, Y., Okuni, H., Ninomiya, K., Sakata, H., Ikebe, K., Maeda, Y., and Kawabata, S.: Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis. Microb. Pathog., 51: 58-68, 2011.

Ogawa, T., Terao, Y., Sakata, H., Okuni, H., Ninomiya, K., Ikebe, K., Maeda, Y., and Kawabata, S.: Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. FEMS Microbiol. Lett. 318: 143-151, 2011.

Kataoka,K., Fujihashi, K., Terao, Y., Gilbert, R. S., Sekine, S., Kobayashi, R., Fukuyama, Y., Kawabata, S., and Fujihashi, K. Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells. PLoS one, 6: e25396, 2011.

Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T.: Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. Microb. Pathog., 50: 148-154, 2011.

Sumitomo, T., Nakata, M., Higashino, M., Jin Y., Terao, Y., Fujinaga, Y., and Kawabata, S. : Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. J. Biol. Chem., 286: 2750-2761, 2011.

Liang, S., Krauss, J.L., Domon, H., McIntosh, M. L., Hosur, K.B., Qu, H., Li, F., Tzekou, A., and Lambris, J.D., Hajishengallis, G.: The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol., 186(2): 869-877, 2011.

Nakagaki, H., Sekine, S., Terao, Y., Toe, M., Tanaka, M., Shizukuishi, S., Ito, H., Kawabata, S., McGhee, J. R., Fujihashi, K., and Kataoka, K.: Fusobacterium nucleatum envelope protein, FomA, is immunogenic and binds to salivary statherin-derived peptide. Infect. Immun., 78: 1185-1192, 2010.

Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T.: Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem. Biophys. Res. Commun., 391:1192-1196, 2010.

Takahashi, N., Honda, T., Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K.: Interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. J. Periodontal Res., 45(4): 512-519, 2010.

Nakajima, T., Honda, T., Domon, H., Okui, T., Kajita, K., Ito, H., Takahashi, N., Maekawa, T., Tabeta, K., and Yamazaki, K.: Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. J. Periodontal Res., 45(1): 116-122, 2010.

Liang, S., Hosur, K.B., Domon, H., and Hajishengallis, G.: Periodontal inflammation and bone loss in aged mice. J. Periodontal Res., 45(4): 574-578, 2010.

Wang, M., Krauss, J. L., Domon, H., Hosur, K. B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J. D., and Hajishengallis G.: Microbial hijacking of complement-toll-like receptor crosstalk. Sci. Signal., 3(109):ra11, 2010.

Yamaguchi, M., Minamide, M., Terao, Y., Isoda, R., Ogawa, T., Yokota, S., Hamada, S., and Kawabata, S.: Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochem. Biophys. Res. Commun., 390: 155-160, 2009.

Terao, Y., Isoda, R., Murakami, J. Hamada, S., and Kawabata, S.: Molecular and biological characterization of novel gtf regulation-associated genes in Streptococcus mutans. Oral Microbiol. Immunol., 24: 211-217, 2009.

Nakata, M., Köller, T. , Moritz, K., Ribardo, D., Jonas, L., McIver, K. S., Sumitomo, T., Terao, Y., Kawabata, S., Podbielski, A., and Kreikemeyer, B.: Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. Infect. Immun., 77: 32-44, 2009.

Wang, M., Liang, S., Hosur, K. B., Domon, H., Yoshimura, F., Amano, A., and Hajishengallis, G.: Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. Oral Microbiol. Immunol., 24(6): 478-484, 2009.

Liang, S., Domon, H., Hosur, K. B., Wang, M., and Hajishengallis, G.: Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech. Ageing Dev., 130(8): 538-546, 2009.

Domon, H., Takahashi, N., Honda, T., Nakajima, T., Tabeta, K., Abiko, Y., and Yamazaki, K.: Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. Clin. Chim. Acta, 401(1-2): 134-140, 2009.

Yamaguchi, M., Terao, Y., Hamada, S., and Kawabata, S.: PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis. J. Biol. Chem., 283: 36272-36279, 2008.

Okamoto, S., Terao, Y., Hasuike, K., Hamada, S., and Kawabata, S.: A novel streptococcal leucine zipper protein (Lzp) that binds to binds to human immunoglobulins. Biochem. Biophys. Res. Commun., 377: 1128-1134, 2008.

Terao, Y., Mori, Y., Yamaguchi, M., Shimizu, Y., Ooe, K., Hamada, S., and Kawabata S.: Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. J. Biol. Chem., 283: 6253-6260, 2008.

Kunitomo, E., Terao, Y., Okamoto, S., Rikimaru, T., Hamada, S., and Kawabata, S.: Molecular and biological characterization of histidine triad protein in group A streptococci. Microbes Infect., 10: 414-423, 2008.

Okamoto, S., Terao, Y., Tamura, Y., Hamada, S., and Kawabata, S.: Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. FEMS Microbiol. Lett., 281: 73-80, 2008.

Itsuki, Y., Saeki, M., Nakahara, H., Egusa, H., Irie, Y., Terao, Y., Kawabata, S., Yatani, H., and Kamisaki, H.: Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett., 582: 2365-2370, 2008.

Honda, T., Aoki, Y., Takahashi, N., Maekawa, T., Nakajima, T., Ito, H., Tabeta, K., Okui, T., Kajita, K., Domon, H., and Yamazaki, K.: Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. Clin. Chim. Acta, 395(1-2): 137-141, 2008.

Domon, H., Honda, T., Oda, T., Yoshie, H., and Yamazaki, K.: Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis. J. Leukoc. Biol., 83(3): 672-679, 2008.

Saeki, M., Irie, Y. Ni, L. Itsuki, Y. Terao, Y., Kawabata, S., and Kamisaki Y.: Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. J. Biol. Chem., 282: 11786-11794, 2007.

Okamaoto, S., Terao, Y., Kaminishi, H., Hamada, S., and Kawabata S.: Inflammatory immune responses by water-insoluble alpha-glucans. J. Dent. Res., 86, 242-248, 2007.

Kajita, K., Honda, T., Amanuma, R., Domon, H., Okui, T., Ito, H., Yoshie, H., Tabeta, K., Nakajima, T., and Yamazaki, K.: Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. Oral Microbiol. Immunol., 22(6): 398-402, 2007.

Yamazaki, K., Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., Kudoh, C., Takashiba, S., Kokeguchi, S., Nishimura, F., Kodama, M., Aizawa, Y., and Oda, H.: Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. Clin. Exp. Immunol., 149(3): 445-452, 2007.

Yamaguchi, M., Terao, Y., Ogawa, T., Takahashi, T., Hamada, S., and Kawabata S.: Role of Streptococcus sanguinis sortase A in bacterial colonization. Microbes Infect., 8: 2791-2796, 2006.

Terao, Y., Yamaguchi, M., Hamada, S., and Kawabata, S.: Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. J. Biol. Chem., 281: 14215-14223, 2006.

Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., and Yamazaki, K.: Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin. Exp. Immunol., 144(1): 35-40, 2006.

Terao, Y., Okamoto, S., Kataoka, K., Hamada, S., and Kawabata, S.: Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding protein. J. Infect. Dis., 192: 2081-2091, 2005.

Yoshida, M., Saeki, M., Itsuki, Y., Irie, Y., Terao, Y., Kawabata, S., Hamada, S., Niwa, H., and Kamisaki, Y.: Search for calcineurin B binding proteins by yeast two-hybrid system. J. Pharma. Sci., 97: 217, 2005.

Okamoto, S., Tamura, Y., Terao, Y., Hamada, S., and Kawabata, S.: Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice. Vaccine., 23: 4852-4859, 2005.

Kaito, C., Kurokawa, K., Matsumoto, M., Terao, Y., Kawabata, S., Hamada, S., and Sekimizu, K.: Silkworm-pathogenic bacteria infection model for identification of novel virulence genes. Mol. Microbiol., 56: 934-944, 2005.

Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y., and Hamada, S.: The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal invasive bacterial-viral superinfection. Infect. Immun., 72: 6068-6075, 2004.

Terao, Y., Kawabata, S., Nakata, M., Nakagawa, I., and Hamada, S.: Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes associated with isolates from toxic shock-like syndrome patients. J. Biol. Chem., 277: 47428-47435, 2002.

Kawabata, S., Tamura, Y., Murakami, J., Terao, Y., Nakagawa, I., and Hamada, S.: A novel, anchorless streptococcal surface protein. Biochem. Biophys. Research., 296: 1329-1333, 2002.

Murakami, J., Kawabata, S., Terao, Y., Kikuchi, K., Totsuka, K., Tamaru, A., Katsukawa, C., Moriya, K., Nakagawa, I., Morisaki, I., and Hamada, S.: Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan from 1994 to 1999. Epidemiol. Infect., 128: 397-404, 2002.

Terao, Y., Kawabata, S., Kunitomo, E., Nakagawa, I., and Hamada, S.: A novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in the adhesion to epithelial cells. Infect. Immun., 70: 993-997, 2002.

Terao, Y., Kawabata, S., Kunitomo, E., Murakami, J., Nakagawa, I., and Hamada, S.: Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Mol. Microbiol., 42: 75-86, 2001.

Kawabata, S., Kunitomo, E., Terao, Y., Nakagawa, I., Kikuchi, K., Totsuka, K., and Hamada, S.: Systemic and mucosal immunization with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge. Infect Immun., 69: 924-930, 2001.

Kawabata, S., Terao, Y., Nakagawa, I., and Hamada, S.: Molecular cloning, sequence, and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene. Oral Microbiol. Immunol., 15: 56-62, 2000.

Kawabata, S., Terao, Y., Fujiwara, T., Nakagawa, I., and Hamada, S.: Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G and serum immunoglobulin G antibodies in mice. Infect. Immun., 67, 5863-5868, 1999.

Fujiwara, T., Terao, Y., Hoshino, T., Kawabata, S., Ooshima, T., Sobue, S., Kimura, S., and Hamada, S.: Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans. FEMS Microbiol. Lett., 161: 331-336, 1998.

Kawabata, S., Terao, Y., Andoh, A., and Hamada, S.: Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii. FEMS Microbiol. Lett., 156: 211-216, 1997.